The museum in Novogrudok appeared only on September 1938 under the initiative of a voluntary scientific community «Mitskevichsky Committee». Soon the Great Patriotic War began, and the house-museum was badly damaged by German bombing. It was reconstructed 14 years later - at 100-th anniversary of the death of A. Mitskevich.
The museum building was completely reconstructed in 1991 year according to the historical original of the XIX century: there were a wing, a barn, a well and a gazebo. In May 2001 an exhibition was opened in the museum. Today the collection consists of about 8000 items, including a variety of things that belonged to the A. Mitskevich”s family (documents, pictures of parents and brothers, personal belongings, etc.), archaeological finds on the areas of the poet”s homeland, books dating the XVIII century, and etc..