This church was built of wood, it has repeatedly suffered from fires. In November 1815, the monastery was once again in flames, which destroyed the church of St. Simeon. The fire completely destroyed in 1819 he monastery, which led to its closure in 1824.
Construction of the stone church was begun only in 1862. November 8, 1865 the church was covered.
Among the relics of St. Simeon Cathedral held a special place relics of St. Martyr Athanasius, the abbot of Brest. Currently, the temple are also relics of St. Nicholas, St. Sergius of Radonezh, the Reverend Euphrosyne of Polotsk, St. Innocent of Radonezh, etc. The church organized a Sunday school and Orthodox library acts sisterhood and published newspapers. «The spiritual messenger» and «Brest eparchial sheets».
Five-domed Orthodox Cathedral of St. Simeon, built in Russian-Byzantine style , is a jewel of the city.The cathedral became a dominant feature of the city and in the dark after the lights had been made.